AAPS_2018_ amorphous solid dispersions in the performance assessment of the risks of crystallization

Amorphous drug recrystallization is amorphous solid dispersions (ASD) one of the biggest risk to the physical instability;This may be on the solubility, release and bioavailability.This study aims to use the experimental design of ASD samples to assess the degree of crystallization of amorphous solid dispersions release effect.